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Listar por autor "Muñoz Castro, Clara"
Mostrando ítems 1-6 de 6
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Artículo
Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer’s disease
Muñoz Castro, Clara; Noori, Ayush; Magdamo, Colin G.; Li, Zhaozhi; Marks, Jordan D.; Frosch, Matthew P.; Das, Sudeshna; Hyman, Bradley T.; Serrano Pozo, Alberto (BMC, 2022)Background Astrocytes and microglia react to Aβ plaques, neurofibrillary tangles, and neurodegeneration in the Alzheimer’s ...
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Artículo
Cytotoxicity and Effects on the Synapsis Induced by Pure Cylindrospermopsin in an E17 Embryonic Murine Primary Neuronal Culture in a Concentration-and Time-Dependent Manner
Hinojosa, María Gracia; Prieto Ortega, Ana Isabel; Muñoz Castro, Clara; Sánchez Mico, María; Vitorica Ferrández, Francisco Javier; Cameán Fernández, Ana María; Jos Gallego, Ángeles Mencía (Multidisciplinary Digital Publishing Institute (MDPI), 2022)Cylindrospermopsin (CYN) is a cyanotoxin whose incidence has been increasing in the last decades. Due to its capacity to ...
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Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology
Romero Molina, Carmen; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Jiménez Muñoz, Sebastián; Fernández Valenzuela, Juan José; Sánchez Mico, María; Muñoz Castro, Clara; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa (Frontiers Media Research Foundation, 2018-11-14)Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer’s disease ...
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Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer’s disease model
Fernández Valenzuela, Juan José; Muñoz Castro, Clara; Jiménez Muñoz, Sebastián; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Gutierrez Pérez, Antonia (Nature Research, 2020)In Alzheimer’s disease (AD), and other tauopathies, microtubule destabilization compromises axonal and synaptic integrity ...
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Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative
Navarro Garrido, Victoria; Sánchez Mejías, Elisabeth; Jiménez Muñoz, Sebastián; Muñoz Castro, Clara; Sánchez Varo, Raquel María; Dávila, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier (Frontiers Media, 2018)Microglial activation has been considered a crucial player in the pathological process of multiple human neurodegenerative ...
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Should we open fire on microglia? Depletion models as tools to elucidate microglial role in health and alzheimer’s disease
Romero Molina, Carmen; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Muñoz Castro, Clara; Sánchez Mico, María; Gutiérrez, Antonia; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa (Multidisciplinary Digital Publishing Institute (MDPI), 2021)Microglia play a critical role in both homeostasis and disease, displaying a wide variety in terms of density, functional ...